Pfizer anti-Covid pill Paxlovid: how and when to use it

The U.S. has given the green light for Pfizer’s anti-Covid pill. U.S. Drug Agency FDA announced Emergency Use Authorization (Eua) for U.S. Company’s Paxlovid Drug, Nirmatrelvir and Ritonavir Tablets packaged together, for the Treatment of Sars-CoV-2 Infection. It is approved for mild to moderate COVID-19 cases in adults and children over 12 weighing at least 40 kilograms, at high risk of progression to severe disease, including hospitalisation and death.

Paxlovid is available only by prescription – the FDA specifies – and therapy must be started as soon as possible after diagnosis, within five days from the onset of symptoms. 

The treatment is given as 3 tablets, 2 of nirmatrelvir and one of ritonavir, to be taken together twice a day for five days, for a total of 30 tablets.

“Today’s authorisation introduces the first anti-Covid-19 treatment to be taken orally”, representing “an important step forward in the fight against this pandemic”, said Patrizia Cavazzoni, head of the Center for drug research and evaluation of the FDA. With the okay to the pill, she adds, “provides a new tool to combat Covid-19 at a crucial time in the pandemic as new variants emerge, and promises to make antiviral treatment more accessible to patients at high risk of progression to severe Covid.”

Pfizer Paxlovid pills: effectiveness

In November 2021, Pfizer announced the results of its clinical trials for Paxlovid. This drug is produced in the form of tablets for oral administration.

The trials were carried out on unvaccinated coronavirus patients who were at high risk of hospitalisation due to health problems (heart disease, diabetics, etc.).

There were six hospitalisations and zero deaths among the 607 trial participants who took Paxlovid. Among the 612 patients taking a placebo, 41 hospitalisations and ten deaths were recorded.

When the drug is prescribed within three days after the onset of symptoms of coronavirus, the drug shows effectiveness against hospitalisation and mortality at the level of 89%. If treatment is started within five days of the onset of symptoms, this rate drops to 85%.

The course of treatment with Paxlovid consists of taking 30 tablets for five days. There are no details on the side effects of Pfizer Paxlovid pills yet.

Effectiveness against COVID-19 variants like Omicron

Paxlovid has nothing to do with spike protein, in which multiple mutations have been identified in the omicron variant. The drug is an inhibitor of the viral protease 3CL, which inhibits the intracellular replication of viral RNA at the stage of proteolysis.

Thus, based on the mechanism of action, there is reason to believe that Paxlovid will retain its effectiveness in relation to omicrons. There is evidence that in vitro Paxlovid is effective against all previously identified variants of SARS-CoV2: alpha, beta, gamma, delta, lambda and mu. In vitro studies have shown that Paxlovid also effectively inhibits the 3CL protease of the omicron variant.

Latest

Harpoon Missile on Snake Island can push Russian Navy 400 km away

This week, Kyiv, for the second time - after an...

US & NATO trained Ukrainian POWs reveal weapons and tactics to the Russians

An increasing number of Armed Forces of Ukraine (AFU)...

PM Modi Pushes for defence reforms, but it is a long road for Self-Reliance and Exports

India achieved its highest annual defence export ambition in...

Ukraine attacks Russian Black Sea oil rig Chernomorneftegaz

At least three people were injured, and eight disappeared...

Newsletter

spot_img

From Same Category

Japan is developing a vaccine that gives permanent immunity to COVID-19

In Japan, a vaccine against COVID-19 is in development,...

Novavax protein vaccine: how it works, side effects of the COVID-19 jab

A protein vaccine differs from the mRNA vaccines (Pfizer...

Another foreign made COVID vaccine, ‘Covovax’, gained WHO approval

WHO has made a written statement regarding the use...

All you want to know about the South African coronavirus variant is called Omicron

WHO has designated the new variant of SARS-CoV-2 detected...

Bharat Biotech’s Covaxin is safe for the short term, says Lancet on preliminary data

Data from Phase 3 trials of the coronavirus vaccine...
Frontier India News Network
Frontier India News Network
Frontier India News Network is the in-house news collection and distribution agency.
spot_imgspot_img

Harpoon Missile on Snake Island can push Russian Navy 400 km away

This week, Kyiv, for the second time - after an unsuccessful attack in May - tried to seize the tactically important Zmeiny Island, popularly known as...

US & NATO trained Ukrainian POWs reveal weapons and tactics to the Russians

An increasing number of Armed Forces of Ukraine (AFU) personnel, including officers, are being captured by Russian troops, who share the information available to...

PM Modi Pushes for defence reforms, but it is a long road for Self-Reliance and Exports

India achieved its highest annual defence export ambition in 2018-19, with INR 107.45 billion ($1.54 billion) in arms exports and export authorizations. After breaking...

LEAVE A REPLY

Please enter your comment!
Please enter your name here